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A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins
Chromatin regulatory complexes localize to specific sites via recognition of post-translational modifications (PTMs) on N-terminal tails of histone proteins (e.g., methylation, acetylation, and phosphorylation). Molecular recognition of modified histones is mediated by ‘reader’ protein subunits. The...
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| Publicado no: | SLAS Discov |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6586500/ https://ncbi.nlm.nih.gov/pubmed/31017815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555219844569 |
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