A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins

Chromatin regulatory complexes localize to specific sites via recognition of post-translational modifications (PTMs) on N-terminal tails of histone proteins (e.g., methylation, acetylation, and phosphorylation). Molecular recognition of modified histones is mediated by ‘reader’ protein subunits. The...

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Udgivet i:SLAS Discov
Main Authors: Rectenwald, Justin M., Hardy, P. Brian, Norris-Drouin, Jacqueline L., Cholensky, Stephanie, James, Lindsey I., Frye, Stephen V., Pearce, Kenneth H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586500/
https://ncbi.nlm.nih.gov/pubmed/31017815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555219844569
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