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Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

Bivalent chemical degraders provide a catalytic route to selectively degrade disease-associated proteins. By linking target-specific ligands with E3 ubiquitin ligase recruiting ligands, these compounds facilitate targeted protein ubiquitination and degradation by the proteasome. Due to the complexit...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Foley, Caroline A., Potjewyd, Frances, Lamb, Kelsey N., James, Lindsey I., Frye, Stephen V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010361/
https://ncbi.nlm.nih.gov/pubmed/31846298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00972
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