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Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay
Bivalent chemical degraders provide a catalytic route to selectively degrade disease-associated proteins. By linking target-specific ligands with E3 ubiquitin ligase recruiting ligands, these compounds facilitate targeted protein ubiquitination and degradation by the proteasome. Due to the complexit...
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| Publicado en: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7010361/ https://ncbi.nlm.nih.gov/pubmed/31846298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00972 |
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