Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

[Image: see text] Protein arginine methyltransferases (PRMTs) play an important role in diverse biological processes. Among the nine known human PRMTs, PRMT3 has been implicated in ribosomal biosynthesis via asymmetric dimethylation of the 40S ribosomal protein S2 and in cancer via interaction with...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Liu, Feng, Li, Fengling, Ma, Anqi, Dobrovetsky, Elena, Dong, Aiping, Gao, Cen, Korboukh, Ilia, Liu, Jing, Smil, David, Brown, Peter J., Frye, Stephen V., Arrowsmith, Cheryl H., Schapira, Matthieu, Vedadi, Masoud, Jin, Jian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319713/
https://ncbi.nlm.nih.gov/pubmed/23445220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3018332
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