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Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

[Image: see text] PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric inhibitor of PRMT3, compound 4....

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Kaniskan, H. Ümit, Eram, Mohammad S., Zhao, Kehao, Szewczyk, Magdalena M., Yang, Xiaobao, Schmidt, Keith, Luo, Xiao, Xiao, Sean, Dai, Miao, He, Feng, Zang, Irene, Lin, Ying, Li, Fengling, Dobrovetsky, Elena, Smil, David, Min, Sun-Joon, Lin-Jones, Jennifer, Schapira, Matthieu, Atadja, Peter, Li, En, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Feng, Yu, Zhengtian, Vedadi, Masoud, Jin, Jian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2017
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808361/
https://ncbi.nlm.nih.gov/pubmed/29244490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01674
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