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Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

[Image: see text] PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric inhibitor of PRMT3, compound 4....

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Pubblicato in:J Med Chem
Autori principali: Kaniskan, H. Ümit, Eram, Mohammad S., Zhao, Kehao, Szewczyk, Magdalena M., Yang, Xiaobao, Schmidt, Keith, Luo, Xiao, Xiao, Sean, Dai, Miao, He, Feng, Zang, Irene, Lin, Ying, Li, Fengling, Dobrovetsky, Elena, Smil, David, Min, Sun-Joon, Lin-Jones, Jennifer, Schapira, Matthieu, Atadja, Peter, Li, En, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Feng, Yu, Zhengtian, Vedadi, Masoud, Jin, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808361/
https://ncbi.nlm.nih.gov/pubmed/29244490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01674
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