Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6

Well-characterized selective inhibitors of protein arginine methyltransferases (PRMTs) are invaluable chemical tools for testing biological and therapeutic hypotheses. Based on 4, a fragment-like inhibitor of type I PRMTs, we conducted structure–activity relationship (SAR) studies and explored three...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Shen, Yudao, Szewczyk, Magdalena M., Eram, Mohammad S., Smil, David, Kaniskan, H. Ümit, de Freitas, Renato Ferreira, Senisterra, Guillermo, Li, Fengling, Schapira, Matthieu, Brown, Peter J., Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, Liu, Jing, Vedadi, Masoud, Jin, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063716/
https://ncbi.nlm.nih.gov/pubmed/27584694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01033
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