A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases

Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological processes. Overexpression of PRMTs has been implicated in various human diseases including cancer. Consequently, selective small-molecule inhibitors of PRMTs have been pursued by both academia and pharmaceutic...

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Bibliografiska uppgifter
I publikationen:ACS Chem Biol
Huvudupphovsmän: Eram, Mohammad S., Shen, Yudao, Szewczyk, Magdalena, Wu, Hong, Senisterra, Guillermo, Li, Fengling, Butler, Kyle V., Kaniskan, H. Ümit, Speed, Brandon A., dela Seña, Carlo, Dong, Aiping, Zeng, Hong, Schapira, Matthieu, Brown, Peter J., Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, Liu, Jing, Vedadi, Masoud, Jin, Jian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798913/
https://ncbi.nlm.nih.gov/pubmed/26598975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00839
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