A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases

Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological processes. Overexpression of PRMTs has been implicated in various human diseases including cancer. Consequently, selective small-molecule inhibitors of PRMTs have been pursued by both academia and pharmaceutic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Eram, Mohammad S., Shen, Yudao, Szewczyk, Magdalena, Wu, Hong, Senisterra, Guillermo, Li, Fengling, Butler, Kyle V., Kaniskan, H. Ümit, Speed, Brandon A., dela Seña, Carlo, Dong, Aiping, Zeng, Hong, Schapira, Matthieu, Brown, Peter J., Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, Liu, Jing, Vedadi, Masoud, Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798913/
https://ncbi.nlm.nih.gov/pubmed/26598975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00839
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados