Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

Protein arginine methyltransferase 6 (PRMT6) plays important roles in several biological processes associated with multiple cancers. Well-characterized potent, selective, and cell-active PRMT6 inhibitors are invaluable tools for testing biological and therapeutic hypotheses. Although there are sever...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Shen, Yudao, Li, Fengling, Szewczyk, Magdalena M., Halabelian, Levon, Park, Kwang-su, Chau, Irene, Dong, Aiping, Zeng, Hong, Chen, He, Meng, Fanye, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Jing, Vedadi, Masoud, Jin, Jian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286362/
https://ncbi.nlm.nih.gov/pubmed/32367723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00406
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