LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of nuclear and cytoplasmic proteins. Although the cellular functions of PRMT5 have not been fully unraveled, it has been impli...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:ACS Med Chem Lett
Autori principali: Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047023/
https://ncbi.nlm.nih.gov/pubmed/30034588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00014
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi