LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the formation of symmetric dimethylarginine in a number of nuclear and cytoplasmic proteins. Although the cellular functions of PRMT5 have not been fully unraveled, it has been impli...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047023/
https://ncbi.nlm.nih.gov/pubmed/30034588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00014
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