High-throughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated microfluidic chip

por Li, Shunbo, Li, Ming, Bougot-Robin, Kristelle, Cao, Wenbin, Yeung Yeung Chau, Irene, Li, Weihua, Wen, Weijia
Publicado em 2013

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

por Eram, Mohammad S., Bustos, Susan P., Lima-Fernandes, Evelyne, Siarheyeva, Alena, Senisterra, Guillermo, Hajian, Taraneh, Chau, Irene, Duan, Shili, Wu, Hong, Dombrovski, Ludmila, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado em 2014

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

por Wernimont, Amy K., Artz, Jennifer D., Finerty, Patrick, Lin, Y., Amani, Mehrnaz, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Tempel, Wolfram, Mackenzie, Farrell, Chau, Irene, Lourido, Sebastian, Sibley, L. David, Hui, Raymond
Publicado em 2010

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor

por Shen, Yudao, Li, Fengling, Szewczyk, Magdalena M., Halabelian, Levon, Park, Kwang-su, Chau, Irene, Dong, Aiping, Zeng, Hong, Chen, He, Meng, Fanye, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Liu, Jing, Vedadi, Masoud, Jin, Jian
Publicado no J Med Chem (2020)

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

por Devkota, Kanchan, Schapira, Matthieu, Perveen, Sumera, Yazdi, Aliakbar Khalili, Li, Fengling, Chau, Irene, Ghiabi, Pegah, Hajian, Taraneh, Loppnau, Peter, Bolotokova, Albina, Satchell, Karla J.F., Wang, Ke, Li, Deyao, Liu, Jing, Smil, David, Luo, Minkui, Jin, Jian, Fish, Paul V., Brown, Peter J., Vedadi, Masoud
Publicado no bioRxiv (2021)

Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

por Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wasney, Gregory A., Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V., Arrowsmith, Cheryl H., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Publicado em 2009

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

por Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado em 2012

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

por Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wigle, Tim J., Wasney, Gregory A., Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L., Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Publicado em 2010

The Cryptosporidium parvum Kinome

por Artz, Jennifer D, Wernimont, Amy K, Allali-Hassani, Abdellah, Zhao, Yong, Amani, Mehrnaz, Lin, Yu-Hui, Senisterra, Guillermo, Wasney, Gregory A, Fedorov, Oleg, King, Oliver, Roos, Annette, Lunin, Vlad V, Qiu, Wei, Finerty, Patrick, Hutchinson, Ashley, Chau, Irene, von Delft, Frank, MacKenzie, Farrell, Lew, Jocelyne, Kozieradzki, Ivona, Vedadi, Masoud, Schapira, Matthieu, Zhang, Chao, Shokat, Kevan, Heightman, Tom, Hui, Raymond
Publicado em 2011

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6

por Shen, Yudao, Li, Fengling, Szewczyk, Magdalena M., Halabelian, Levon, Chau, Irene, Eram, Mohammad S., Seña, Carlo Dela, Park, Kwang-Su, Meng, Fanye, Chen, He, Zeng, Hong, McLeod, David, Zepeda-Velázquez, Carlos A., Campbell, Robert M., Mader, Mary M., Watson, Brian M., Schapira, Matthieu, Arrowsmith, Cheryl H., Al-Awar, Rima, Barsyte-Lovejoy, Dalia, Kaniskan, H. Ümit, Brown, Peter J., Vedadi, Masoud, Jin, Jian
Publicado no J Med Chem (2021)

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

por Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, Dimaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Publicado em 2011