The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis

Por Chorba, John S., Shokat, Kevan M.
Publicado em 2014

Disease-causing mutations in the G protein Gαs subvert the roles of GDP and GTP

Por Hu, Qi, Shokat, Kevan M.
Publicado no Cell (2018)

Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins

Por Zhang, Ziyang, Shokat, Kevan M.
Publicado no Angew Chem Int Ed Engl (2019)

Targeting osteosarcoma

Por Reed, Darien E., Shokat, Kevan M.
Publicado no Proc Natl Acad Sci U S A (2014)

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1

Por Lazarus, Michael B., Shokat, Kevan M.
Publicado no Bioorg Med Chem (2015)

INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC

Por Reed, Darien E., Shokat, Kevan M.
Publicado no Mol Cancer Res (2017)

Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct

Por Bateman, Raynard, Rauh, Daniel, Shokat, Kevan M.
Publicado em 2007

A Crosslinker Based on a Tethered Electrophile for Mapping Kinase-Substrate Networks

Por Riel-Mehan, Megan M, Shokat, Kevan M
Publicado no Chem Biol (2014)

Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

Por Dar, Arvin C., Lopez, Michael S., Shokat, Kevan M.
Publicado em 2008

Targeting the cancer kinome through polypharmacology

Por Knight, Zachary A., Lin, Henry, Shokat, Kevan M.
Publicado em 2010

Recognizing and exploiting differences between RNAi and small-molecule inhibitors

Por Weiss, William A, Taylor, Stephen S, Shokat, Kevan M
Publicado em 2007

Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response

Por Lazarus, Michael B., Levin, Rebecca S., Shokat, Kevan M.
Publicado no Cell Signal (2016)

Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype

Por Chorba, John S., Galvan, Adri M., Shokat, Kevan M.
Publicado no J Biol Chem (2018)

Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.

Por Chorba, John S., Galvan, Adri M., Shokat, Kevan M.
Publicado no J Biol Chem (2018)

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Por Chorba, John S., Galvan, Adri M., Shokat, Kevan M.
Publicado no J Vis Exp (2018)

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

Por Shah, Kavita, Liu, Yi, Deirmengian, Carl, Shokat, Kevan M.
Publicado em 1997

Bio-orthogonal Affinity Purification of Direct Kinase Substrates

Por Allen, Jasmina J., Lazerwith, Scott E., Shokat, Kevan M.
Publicado em 2005

Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

Por Cohen, Michael S., Zhang, Chao, Shokat, Kevan M., Taunton, Jack
Publicado em 2005

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

Por Lazarus, Michael B., Novotny, Chris J., Shokat, Kevan M.
Publicado no ACS Chem Biol (2014)

Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2

Por Benjamin, Kirsten R., Zhang, Chao, Shokat, Kevan M., Herskowitz, Ira
Publicado em 2003