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Targeting the cancer kinome through polypharmacology

Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies...

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Autors principals: Knight, Zachary A., Lin, Henry, Shokat, Kevan M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880454/
https://ncbi.nlm.nih.gov/pubmed/20094047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2787
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