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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
The complexity of cancer has led to recent interest in polypharmacological approaches for developing kinase-inhibitor drugs; however, optimal kinase-inhibition profiles remain difficult to predict. Using a Ret-kinase-driven Drosophila model of multiple endocrine neoplasia type 2 and kinome-wide drug...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3703503/ https://ncbi.nlm.nih.gov/pubmed/22678283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11127 |
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