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Chemical genetic strategy for targeting protein kinases based on covalent complementarity
The conserved nature of the ATP-binding site of the > 500 human kinases renders the development of specific inhibitors a challenging task. A widely used chemical genetic strategy to overcome the specificity challenge exploits a large-to-small mutation of the gatekeeper residue (a conserved hydrop...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174669/ https://ncbi.nlm.nih.gov/pubmed/21852571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111239108 |
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