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Targeting the cancer kinome through polypharmacology
Kinase inhibitors are the largest class of new cancer drugs. However, it is already apparent that most tumours can escape from the inhibition of any single kinase. If it is necessary to inhibit multiple kinases, how do we choose which ones? In this Opinion article, we discuss some of the strategies...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880454/ https://ncbi.nlm.nih.gov/pubmed/20094047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2787 |
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