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Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1

Energy homeostasis in eukaryotic cells is a complex and fundamental process that is misregulated in several human diseases. A key component of energy regulation is a process called autophagy that involves the recycling of cellular components. There has been much recent interest in studying the mecha...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Lazarus, Michael B., Shokat, Kevan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864979/
https://ncbi.nlm.nih.gov/pubmed/26275681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.034
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