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Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins
Here we report the design, synthesis and characterization of bifunctional chemical ligands that induce the association of Ras with ubiquitously expressed immunophilin proteins such as FKBP12 and cyclophilin A. We show this approach is applicable to two distinct Ras ligand scaffolds, and that both th...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980260/ https://ncbi.nlm.nih.gov/pubmed/31557383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910124 |
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