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Bifunctional Small Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins
Here we report the design, synthesis and characterization of bifunctional chemical ligands that induce the association of Ras with ubiquitously expressed immunophilin proteins such as FKBP12 and cyclophilin A. We show this approach is applicable to two distinct Ras ligand scaffolds, and that both th...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980260/ https://ncbi.nlm.nih.gov/pubmed/31557383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201910124 |
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