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GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf
[Image: see text] We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound state and block Ras-Raf int...
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| Vydáno v: | ACS Cent Sci |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American
Chemical Society
2020
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7596874/ https://ncbi.nlm.nih.gov/pubmed/33145412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00514 |
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