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GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

[Image: see text] We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound state and block Ras-Raf int...

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書誌詳細
出版年:ACS Cent Sci
主要な著者: Zhang, Ziyang, Gao, Rong, Hu, Qi, Peacock, Hayden, Peacock, D. Matthew, Dai, Shizhong, Shokat, Kevan M., Suga, Hiroaki
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2020
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596874/
https://ncbi.nlm.nih.gov/pubmed/33145412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00514
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