GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

[Image: see text] We report the identification of three cyclic peptide ligands of K-Ras(G12D) using an integrated in vitro translation–mRNA display selection platform. These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound state and block Ras-Raf int...

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Udgivet i:ACS Cent Sci
Main Authors: Zhang, Ziyang, Gao, Rong, Hu, Qi, Peacock, Hayden, Peacock, D. Matthew, Dai, Shizhong, Shokat, Kevan M., Suga, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596874/
https://ncbi.nlm.nih.gov/pubmed/33145412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00514
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