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Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides()

Ras genes are frequently activated in human cancers, but the mutant Ras proteins remain largely “undruggable” by the conventional small-molecule approach due to absence of any obvious binding pockets on their surfaces. By screening a combinatorial peptide library followed by structure-activity relat...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Upadhyaya, Punit, Qian, Ziqing, Selner, Nicholas G., Clippinger, Sarah R., Wu, Zhengrong, Briesewitz, Roger, Pei, Dehua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591930/
https://ncbi.nlm.nih.gov/pubmed/25950772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502763
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