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Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides
Intracellular protein-protein interactions (PPIs) are challenging targets for conventional drug modalities, because small molecules generally do not bind to their large, flat binding sites with high affinity, whereas monoclonal antibodies cannot cross the cell membrane to reach the targets. Cyclic p...
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| Publicado no: | Curr Opin Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474178/ https://ncbi.nlm.nih.gov/pubmed/28388463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2017.03.011 |
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