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Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides()
Ras genes are frequently activated in human cancers, but the mutant Ras proteins remain largely “undruggable” by the conventional small-molecule approach due to absence of any obvious binding pockets on their surfaces. By screening a combinatorial peptide library followed by structure-activity relat...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4591930/ https://ncbi.nlm.nih.gov/pubmed/25950772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502763 |
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