A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Oncogenic activation of RAS genes via point mutations occurs in 20%–30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a lar...

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Publicat a:Cell
Autors principals: Athuluri-Divakar, Sai Krishna, Carpio, Rodrigo Vasquez-Del, Dutta, Kaushik, Baker, Stacey J., Cosenza, Stephen C., Basu, Indranil, Gupta, Yogesh K., Reddy, M.V. Ramana, Ueno, Lynn, Hart, Jonathan R., Vogt, Peter K., Mulholland, David, Guha, Chandan, Aggarwal, Aneel K., Reddy, E. Premkumar
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006944/
https://ncbi.nlm.nih.gov/pubmed/27104980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.03.045
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