A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Oncogenic activation of RAS genes via point mutations occurs in 20%–30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a lar...

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Publicado en:Cell
Main Authors: Athuluri-Divakar, Sai Krishna, Carpio, Rodrigo Vasquez-Del, Dutta, Kaushik, Baker, Stacey J., Cosenza, Stephen C., Basu, Indranil, Gupta, Yogesh K., Reddy, M.V. Ramana, Ueno, Lynn, Hart, Jonathan R., Vogt, Peter K., Mulholland, David, Guha, Chandan, Aggarwal, Aneel K., Reddy, E. Premkumar
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5006944/
https://ncbi.nlm.nih.gov/pubmed/27104980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.03.045
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