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Unifying principles of bifunctional, proximity-inducing small molecules

Nature uses a variety of tools to mediate the flow of information in cells, many of which control distances between key biomacromolecules. Researchers have thus generated compounds whose activities stem from interactions with two (or more) proteins simultaneously. In this Perspective, we describe ho...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Gerry, Christopher J., Schreiber, Stuart L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312755/
https://ncbi.nlm.nih.gov/pubmed/32198490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0469-1
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