Yüklüyor......
Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.
Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is over expressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth and the di-methylation of p53 K373 results in the inactivation of p53. Initial SAR...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920043/ https://ncbi.nlm.nih.gov/pubmed/20614940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100478y |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|