Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is over expressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth and the di-methylation of p53 K373 results in the inactivation of p53. Initial SAR...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wigle, Tim J., Wasney, Gregory A., Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L., Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920043/
https://ncbi.nlm.nih.gov/pubmed/20614940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100478y
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