Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is over expressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth and the di-methylation of p53 K373 results in the inactivation of p53. Initial SAR...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wigle, Tim J., Wasney, Gregory A., Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L., Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920043/
https://ncbi.nlm.nih.gov/pubmed/20614940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100478y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados