Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT(2C) Receptor Agonists

Por Rouquet, Guy, Moore, Dianna E., Spain, Malcolm, Allwood, Daniel M., Battilocchio, Claudio, Blakemore, David C., Fish, Paul V., Jenkinson, Stephen, Jessiman, Alan S., Ley, Steven V., McMurray, Gordon, Storer, R. Ian
Publicado no ACS Med Chem Lett (2015)

PFI-1 – A highly Selective Protein Interaction Inhibitor Targeting BET Bromodomains

Por Picaud, Sarah, Costa, David Da, Thanasopoulou, Angeliki, Filippakopoulos, Panagis, Fish, Paul V., Philpott, Martin, Fedorov, Oleg, Brennan, Paul, Bunnage, Mark E., Owen, Dafydd R., Bradner, James E., Taniere, Philippe, O’Sullivan, Brendan, Müller, Susanne, Schwaller, Juerg, Stankovic, Tatjana, Knapp, Stefan
Publicado em 2013

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Por Fish, Paul V., Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E., Bunnage, Mark E., Cook, Andrew S., Federov, Oleg, Gerstenberger, Brian S., Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka, Karl, Owen, Dafydd R., Philpott, Martin, Picaud, Sarah, Primiano, Michael J., Ralph, Michael J., Sciammetta, Nunzio, Trzupek, John D.
Publicado em 2012

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Por Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.
Publicado em 2014