Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

Por Newman, Joseph A., Aitkenhead, Hazel, Savitsky, Pavel, Gileadi, Opher
Publicado no Nucleic Acids Res (2017)

Frapid: achieving full automation of FRAP for chemical probe validation

Por Yapp, Clarence, Rogers, Catherine, Savitsky, Pavel, Philpott, Martin, Müller, Susanne
Publicado no Biomed Opt Express (2016)

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions

Por Elkins, Jonathan M., Papagrigoriou, Evangelos, Berridge, Georgina, Yang, Xiaowen, Phillips, Claire, Gileadi, Carina, Savitsky, Pavel, Doyle, Declan A.
Publicado em 2007

High-throughput production of human proteins for crystallization: The SGC experience

Por Savitsky, Pavel, Bray, James, Cooper, Christopher D.O., Marsden, Brian D., Mahajan, Pravin, Burgess-Brown, Nicola A., Gileadi, Opher
Publicado em 2010

Expression and purification of recombinant human inward rectifier K(+) (KCNJ) channels in Saccharomyces cerevisiae

Por D’Avanzo, Nazzareno, Cheng, Wayland W.L., Xia, Xiaobing, Dong, Liang, Savitsky, Pavel, Nichols, Colin G., Doyle, Declan A.
Publicado em 2010

Mechanistic Insight into the Interaction of BLM helicase with Intra-strand G-quadruplex Structures

Por Chatterjee, Sujoy, Zagelbaum, Jennifer, Savitsky, Pavel, Sturzenegger, Andreas, Huttner, Diana, Janscak, Pavel, Hickson, Ian D, Gilaedi, Opher, Rothenberg, Eli
Publicado no Nat Commun (2014)

Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Por Filippakopoulos, Panagis, Low, Andrew, Sharpe, Timothy D., Uppenberg, Jonas, Yao, Shenggen, Kuang, Zhihe, Savitsky, Pavel, Lewis, Rowena S., Nicholson, Sandra E., Norton, Raymond S., Bullock, Alex N.
Publicado em 2010

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Por Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.
Publicado em 2013

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Por Barr, Alastair J., Ugochukwu, Emilie, Lee, Wen Hwa, King, Oliver N.F., Filippakopoulos, Panagis, Alfano, Ivan, Savitsky, Pavel, Burgess-Brown, Nicola A., Müller, Susanne, Knapp, Stefan
Publicado em 2009

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Por Newman, Joseph A., Savitsky, Pavel, Allerston, Charles K., Bizard, Anna H., Özer, Özgün, Sarlós, Kata, Liu, Ying, Pardon, Els, Steyaert, Jan, Hickson, Ian D., Gileadi, Opher
Publicado no Nucleic Acids Res (2015)

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

Por Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Publicado no J Med Chem (2015)

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation

Por Keates, Tracy, Cooper, Christopher D.O., Savitsky, Pavel, Allerston, Charles K., Phillips, Claire, Hammarström, Martin, Daga, Neha, Berridge, Georgina, Mahajan, Pravin, Burgess-Brown, Nicola A., Müller, Susanne, Gräslund, Susanne, Gileadi, Opher
Publicado em 2012

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Por Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis
Publicado em 2013

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

Por Savitsky, Pavel, Krojer, Tobias, Fujisawa, Takao, Lambert, Jean-Philippe, Picaud, Sarah, Wang, Chen-Yi, Shanle, Erin K., Krajewski, Krzysztof, Friedrichsen, Hans, Kanapin, Alexander, Goding, Colin, Schapira, Matthieu, Samsonova, Anastasia, Strahl, Brian D., Gingras, Anne-Claude, Filippakopoulos, Panagis
Publicado no Cell Rep (2016)

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells

Por Nguyen, Giang Huong, Dexheimer, Thomas S., Rosenthal, Andrew S., Chu, Wai Kit, Singh, Dharmendra Kumar, Mosedale, Georgina, Bachrati, Csanád Z., Schultz, Lena, Sakurai, Masaaki, Savitsky, Pavel, Abu, Mika, McHugh, Peter J., Bohr, Vilhelm A., Harris, Curtis C., Jadhav, Ajit, Gileadi, Opher, Maloney, David J., Simeonov, Anton, Hickson, Ian D.
Publicado em 2013

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Anal...

Por Myrianthopoulos, Vassilios, Gaboriaud-Kolar, Nicolas, Tallant, Cynthia, Hall, Michelle-Lynn, Grigoriou, Stylianos, Brownlee, Peter Moore, Fedorov, Oleg, Rogers, Catherine, Heidenreich, David, Wanior, Marek, Drosos, Nikolaos, Mexia, Nikitia, Savitsky, Pavel, Bagratuni, Tina, Kastritis, Efstathios, Terpos, Evangelos, Filippakopoulos, Panagis, Müller, Susanne, Skaltsounis, Alexios-Leandros, Downs, Jessica Ann, Knapp, Stefan, Mikros, Emmanuel
Publicado no J Med Chem (2016)

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

Por Froese, D. Sean, Forouhar, Farhad, Tran, Timothy H., Vollmar, Melanie, Kim, Yi Seul, Lew, Scott, Neely, Helen, Seetharaman, Jayaraman, Shen, Yang, Xiao, Rong, Acton, Thomas B., Everett, John K., Cannone, Giuseppe, Puranik, Sriharsha, Savitsky, Pavel, Krojer, Tobias, Pilka, Ewa S., Kiyani, Wasim, Lee, Wen Hwa, Marsden, Brian D., von Delft, Frank, Allerston, Charles K., Spagnolo, Laura, Gileadi, Opher, Montelione, Gaetano T., Oppermann, Udo, Yue, Wyatt W., Tong, Liang
Publicado em 2013

Assessing histone demethylase inhibitors in cells: lessons learned

Por Hatch, Stephanie B., Yapp, Clarence, Montenegro, Raquel C., Savitsky, Pavel, Gamble, Vicki, Tumber, Anthony, Ruda, Gian Filippo, Bavetsias, Vassilios, Fedorov, Oleg, Atrash, Butrus, Raynaud, Florence, Lanigan, Rachel, Carmichael, LeAnne, Tomlin, Kathy, Burke, Rosemary, Westaway, Susan M., Brown, Jack A., Prinjha, Rab K., Martinez, Elisabeth D., Oppermann, Udo, Schofield, Christopher J., Bountra, Chas, Kawamura, Akane, Blagg, Julian, Brennan, Paul E., Rossanese, Olivia, Müller, Susanne
Publicado no Epigenetics Chromatin (2017)

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Por Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.
Publicado no Cell Chem Biol (2017)

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Por Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian
Publicado no J Med Chem (2016)