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Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF
[Image: see text] TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein int...
Gespeichert in:
Veröffentlicht in: | J Med Chem |
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Hauptverfasser: | , , , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
American Chemical
Society
2015
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Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4770308/ https://ncbi.nlm.nih.gov/pubmed/25974391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00458 |
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