Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

[Image: see text] TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein int...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Med Chem
Главные авторы: Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2015
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770308/
https://ncbi.nlm.nih.gov/pubmed/25974391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00458
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы