Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

[Image: see text] TRIM24 is a transcriptional regulator as well as an E3 ubiquitin ligase. It is overexpressed in diverse tumors, and high expression levels have been linked to poor prognosis in breast cancer patients. TRIM24 contains a PHD/bromodomain offering the opportunity to develop protein int...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770308/
https://ncbi.nlm.nih.gov/pubmed/25974391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00458
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker