Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

[Image: see text] Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1–3 in...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Meier, Julia C., Tallant, Cynthia, Fedorov, Oleg, Witwicka, Hanna, Hwang, Sung-Yong, van Stiphout, Ruud G., Lambert, Jean-Philippe, Rogers, Catherine, Yapp, Clarence, Gerstenberger, Brian S., Fedele, Vita, Savitsky, Pavel, Heidenreich, David, Daniels, Danette L., Owen, Dafydd R., Fish, Paul V., Igoe, Niall M., Bayle, Elliott D., Haendler, Bernard, Oppermann, Udo C.T., Buffa, Francesca, Brennan, Paul E., Müller, Susanne, Gingras, Anne Claude, Odgren, Paul R., Birnbaum, Mark J., Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662925/
https://ncbi.nlm.nih.gov/pubmed/28849908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00481
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