Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene transcription programs during development and stem cell differentiation. BAF complexes contain an ATP (adenosine 5′-triphosphate)–driven remodeling enzyme...

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Udgivet i:Sci Adv
Main Authors: Fedorov, Oleg, Castex, Josefina, Tallant, Cynthia, Owen, Dafydd R., Martin, Sarah, Aldeghi, Matteo, Monteiro, Octovia, Filippakopoulos, Panagis, Picaud, Sarah, Trzupek, John D., Gerstenberger, Brian S., Bountra, Chas, Willmann, Dominica, Wells, Christopher, Philpott, Martin, Rogers, Catherine, Biggin, Philip C., Brennan, Paul E., Bunnage, Mark E., Schüle, Roland, Günther, Thomas, Knapp, Stefan, Müller, Susanne
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681344/
https://ncbi.nlm.nih.gov/pubmed/26702435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500723
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