The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers o...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Medchemcomm
Autors principals: Hay, Duncan, Fedorov, Oleg, Filippakopoulos, Panagis, Martin, Sarah, Philpott, Martin, Picaud, Sarah, Hewings, David S., Uttakar, Sagar, Heightman, Tom D., Conway, Stuart J., Knapp, Stefan, Brennan, Paul E.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678575/
https://ncbi.nlm.nih.gov/pubmed/26682033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20189E
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars