The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers o...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Medchemcomm
Huvudupphovsmän: Hay, Duncan, Fedorov, Oleg, Filippakopoulos, Panagis, Martin, Sarah, Philpott, Martin, Picaud, Sarah, Hewings, David S., Uttakar, Sagar, Heightman, Tom D., Conway, Stuart J., Knapp, Stefan, Brennan, Paul E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678575/
https://ncbi.nlm.nih.gov/pubmed/26682033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20189E
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk