The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers o...

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Dettagli Bibliografici
Pubblicato in:Medchemcomm
Autori principali: Hay, Duncan, Fedorov, Oleg, Filippakopoulos, Panagis, Martin, Sarah, Philpott, Martin, Picaud, Sarah, Hewings, David S., Uttakar, Sagar, Heightman, Tom D., Conway, Stuart J., Knapp, Stefan, Brennan, Paul E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678575/
https://ncbi.nlm.nih.gov/pubmed/26682033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20189E
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