[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains

[Image: see text] Bromodomains are gaining increasing interest as drug targets. Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside the BET family such as BRD9, CEC...

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Detalhes bibliográficos
Main Authors: Fedorov, Oleg, Lingard, Hannah, Wells, Chris, Monteiro, Octovia P., Picaud, Sarah, Keates, Tracy, Yapp, Clarence, Philpott, Martin, Martin, Sarah J., Felletar, Ildiko, Marsden, Brian D., Filippakopoulos, Panagis, Müller, Susanne, Knapp, Stefan, Brennan, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906316/
https://ncbi.nlm.nih.gov/pubmed/24313754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401568s
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