LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor**

The bromodomain-containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin-remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 has been reported despite its potential value as a biological tool or as a lead for future therapeutics. The quinolone-fused lactam...

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Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Clark, Peter G K, Vieira, Lucas C C, Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C, Rogers, Catherine M, Monteiro, Octovia P, Bennett, James M, Baronio, Roberta, Müller, Susanne, Daniels, Danette L, Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E, Dixon, Darren J
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY-VCH Verlag 2015
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449114/
https://ncbi.nlm.nih.gov/pubmed/25864491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201501394
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