LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

The bromodomain‐containing proteins BRD9 and BRD7 are part of the human SWI/SNF chromatin‐remodeling complexes BAF and PBAF. To date, no selective inhibitor for BRD7/9 has been reported despite its potential value as a biological tool or as a lead for future therapeutics. The quinolone‐fused lactam...

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Pubblicato in:Angew Chem Weinheim Bergstr Ger
Autori principali: Clark, Peter G. K., Vieira, Lucas C. C., Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C., Rogers, Catherine M., Monteiro, Octovia P., Bennett, James M., Baronio, Roberta, Müller, Susanne, Daniels, Danette L., Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E., Dixon, Darren J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY‐VCH Verlag 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871321/
https://ncbi.nlm.nih.gov/pubmed/27346896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ange.201501394
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