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Mechanistic Insight into the Interaction of BLM helicase with Intra-strand G-quadruplex Structures
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strand...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4243535/ https://ncbi.nlm.nih.gov/pubmed/25418155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6556 |
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