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BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation

Bloom syndrome (BS) is a rare genetic disorder characterized by genomic instability and a high predisposition to cancer. The gene defective in BS, BLM, encodes a member of the RecQ family of 3′–5′ DNA helicases, and is proposed to function in recombinational repair during DNA replication. Here, we h...

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Detalhes bibliográficos
Main Authors: Yodh, Jaya G, Stevens, Benjamin C, Kanagaraj, Radhakrishnan, Janscak, Pavel, Ha, Taekjip
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646154/
https://ncbi.nlm.nih.gov/pubmed/19165145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.298
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