Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases

Por Bonnici, Joanna, Tumber, Anthony, Kawamura, Akane, Schofield, Christopher J.
Publicado no Philos Trans R Soc Lond B Biol Sci (2018)

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations

Por Hancock, Rebecca L, Masson, Norma, Dunne, Kate, Flashman, Emily, Kawamura, Akane
Publicado no ACS Chem Biol (2017)

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities

Por Singh, Kamayani, Davies, Graham, Alenazi, Yara, Eaton, James R. O., Kawamura, Akane, Bhattacharya, Shoumo
Publicado no Sci Rep (2017)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system

Por Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Kawamura, Akane, Zhang, Xiaoyan, Hein, David W., Sim, Edith
Publicado em 2008

Targeting histone lysine demethylases — Progress, challenges, and the future()

Por Thinnes, Cyrille C., England, Katherine S., Kawamura, Akane, Chowdhury, Rasheduzzaman, Schofield, Christopher J., Hopkinson, Richard J.
Publicado no Biochim Biophys Acta Gene Regul Mech (2014)

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1

Por Kawamura, Akane, Westwood, Isaac, Wakefield, Larissa, Long, Hilary, Zhang, Naixia, Walters, Kylie, Redfield, Christina, Sim, Edith
Publicado em 2008

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets

Por Alenazi, Yara, Singh, Kamayani, Davies, Graham, Eaton, James R. O., Elders, Philip, Kawamura, Akane, Bhattacharya, Shoumo
Publicado no Sci Rep (2018)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Por Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Schiller, Rachel, Ge, Wei, Kawamura, Akane, Schofield, Christopher J.
Publicado no Nat Commun (2016)

Formaldehyde quantification using ampicillin is not selective

Por Reinbold, Raphael, John, Tobias, Spingardi, Paolo, Kawamura, Akane, Thompson, Amber L., Schofield, Christopher J., Hopkinson, Richard J.
Publicado no Sci Rep (2019)

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

Por Williams, Sophie T, Walport, Louise J, Hopkinson, Richard J, Madden, Sarah K, Chowdhury, Rasheduzzaman, Schofield, Christopher J, Kawamura, Akane
Publicado no Epigenetics (2015)

Modulating carnitine levels by targeting its biosynthesis pathway – selective inhibition of γ-butyrobetaine hydroxylase

Por Rydzik, Anna M., Chowdhury, Rasheduzzaman, Kochan, Grazyna T., Williams, Sophie T., McDonough, Michael A., Kawamura, Akane, Schofield, Christopher J.
Publicado no Chem Sci (2014)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

Por Laurieri, Nicola, Kawamura, Akane, Westwood, Isaac M, Varney, Amy, Morris, Elizabeth, Russell, Angela J, Stanley, Lesley A, Sim, Edith
Publicado no BMC Pharmacol Toxicol (2014)

KDM4A regulates HIF-1 levels through H3K9me3

Por Dobrynin, Grzegorz, McAllister, Tom E., Leszczynska, Katarzyna B., Ramachandran, Shaliny, Krieg, Adam J., Kawamura, Akane, Hammond, Ester M.
Publicado no Sci Rep (2017)

Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation

Por Hancock, Rebecca L., Abboud, Martine I., Smart, Tristan J., Flashman, Emily, Kawamura, Akane, Schofield, Christopher J., Hopkinson, Richard J.
Publicado no Chembiochem (2018)

Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

Por Walport, Louise J., Hopkinson, Richard J., Chowdhury, Rasheduzzaman, Zhang, Yijia, Bonnici, Joanna, Schiller, Rachel, Kawamura, Akane, Schofield, Christopher J.
Publicado no FEBS Lett (2018)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding

Por Kawamura, Akane, Tumber, Anthony, Rose, Nathan R., King, Oliver N. F., Daniel, Michelle, Oppermann, Udo, Heightman, Tom D., Schofield, Christopher
Publicado no Anal Biochem (2010)

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Por Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Publicado no Bioorg Med Chem (2018)

The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins

Por Eaton, James R. O., Alenazi, Yara, Singh, Kamayani, Davies, Graham, Geis-Asteggiante, Lucia, Kessler, Benedikt, Robinson, Carol V., Kawamura, Akane, Bhattacharya, Shoumo
Publicado no J Biol Chem (2018)

Is JmjC Oxygenase Catalysis Limited to Demethylation?**

Por Hopkinson, Richard J, Walport, Louise J, Münzel, Martin, Rose, Nathan R, Smart, Tristan J, Kawamura, Akane, Claridge, Timothy D W, Schofield, Christopher J
Publicado em 2013

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer

Por Saraç, Hilal, Morova, Tunç, Pires, Elisabete, McCullagh, James, Kaplan, Anıl, Cingöz, Ahmet, Bagci-Onder, Tugba, Önder, Tamer, Kawamura, Akane, Lack, Nathan A.
Publicado no Oncogene (2019)