Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

BACKGROUND: The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme with poor activity and human NATP is a pseudogene. (MOUSE)Nat2 is orthologous...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:BMC Pharmacol Toxicol
Hlavní autoři: Laurieri, Nicola, Kawamura, Akane, Westwood, Isaac M, Varney, Amy, Morris, Elizabeth, Russell, Angela J, Stanley, Lesley A, Sim, Edith
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258814/
https://ncbi.nlm.nih.gov/pubmed/25432241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-68
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky