Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

BACKGROUND: The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme with poor activity and human NATP is a pseudogene. (MOUSE)Nat2 is orthologous...

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Publicado en:BMC Pharmacol Toxicol
Autores principales: Laurieri, Nicola, Kawamura, Akane, Westwood, Isaac M, Varney, Amy, Morris, Elizabeth, Russell, Angela J, Stanley, Lesley A, Sim, Edith
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258814/
https://ncbi.nlm.nih.gov/pubmed/25432241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-68
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