Drug metabolism and antibiotic resistance in micro‐organisms

Autor Sim, Edith, Ryan, Ali
Vydáno v Br J Pharmacol (2017)

Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa

Autor Westwood, Isaac M, Sim, Edith
Vydáno 2007

Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.

Autor Boukouvala, Sotiria, Price, Naomi, Plant, Kathryn E, Sim, Edith
Vydáno 2003

Cloning and Characterization of Arylamine N-Acetyltransferase Genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: Increased Expression Results in Isoniazid Resistanc...

Autor Payton, Mark, Auty, Roy, Delgoda, Rupika, Everett, Martin, Sim, Edith
Vydáno 1999

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

Autor Johnson, Nichola, Bell, Peter, Jonovska, Vesna, Budge, Marc, Sim, Edith
Vydáno 2004

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis

Autor Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith, Noble, Martin
Vydáno 2005

Activation of nitrofurazone by azoreductases: multiple activities in one enzyme

Autor Ryan, Ali, Kaplan, Elise, Laurieri, Nicola, Lowe, Edward, Sim, Edith
Vydáno 2011

Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism

Autor Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Griffiths, William J., Sim, Edith
Vydáno 2007

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

Autor Ryan, Ali, Wang, Chan-Ju, Laurieri, Nicola, Westwood, Isaac, Sim, Edith
Vydáno v Protein Cell (2010)

Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases

Autor Ballester, Pedro J., Westwood, Isaac, Laurieri, Nicola, Sim, Edith, Richards, W. Graham
Vydáno 2010

Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature

Autor Hein, David W., Boukouvala, Sotiria, Grant, Denis M., Minchin, Rodney F., Sim, Edith
Vydáno 2008

Purification of human C3b inactivator by monoclonal-antibody affinity chromatography

Autor Hsiung, Li-min, Barclay, A. Neil, Brandon, Malcolm R., Sim, Edith, Porter, Rodney R.
Vydáno 1982

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

Autor Sandy, James, Mushtaq, Adeel, Holton, Simon J., Schartau, Pamela, Noble, Martin E. M., Sim, Edith
Vydáno 2005

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system

Autor Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Kawamura, Akane, Zhang, Xiaoyan, Hein, David W., Sim, Edith
Vydáno 2008

Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

Autor Wang, Chan-Ju, Laurieri, Nicola, Abuhammad, Areej, Lowe, Edward, Westwood, Isaac, Ryan, Ali, Sim, Edith
Vydáno 2009

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

Autor Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Garman, Elspeth F., Sim, Edith
Vydáno v Protein Cell (2010)

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1

Autor Kawamura, Akane, Westwood, Isaac, Wakefield, Larissa, Long, Hilary, Zhang, Naixia, Walters, Kylie, Redfield, Christina, Sim, Edith
Vydáno 2008

Downregulation of Hepatic Acetylation of Drugs in Chronic Renal Failure

Autor Simard, Emilie, Naud, Judith, Michaud, Josée, Leblond, Francois A., Bonnardeaux, Alain, Guillemette, Chantal, Sim, Edith, Pichette, Vincent
Vydáno 2008

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues

Autor Tsirka, Theodora, Konstantopoulou, Maria, Sabbagh, Audrey, Crouau-Roy, Brigitte, Ryan, Ali, Sim, Edith, Boukouvala, Sotiria, Fakis, Giannoulis
Vydáno v Sci Rep (2018)

Exploration of Piperidinols as Potential Antitubercular Agents

Autor Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela J., Morris, Garrett M., Finn, Paul W., Sim, Edith
Vydáno v Molecules (2014)