Drug metabolism and antibiotic resistance in micro‐organisms

af Sim, Edith, Ryan, Ali
Udgivet i Br J Pharmacol (2017)

Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa

af Westwood, Isaac M, Sim, Edith
Udgivet 2007

Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice.

af Boukouvala, Sotiria, Price, Naomi, Plant, Kathryn E, Sim, Edith
Udgivet 2003

Cloning and Characterization of Arylamine N-Acetyltransferase Genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: Increased Expression Results in Isoniazid Resistanc...

af Payton, Mark, Auty, Roy, Delgoda, Rupika, Everett, Martin, Sim, Edith
Udgivet 1999

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

af Johnson, Nichola, Bell, Peter, Jonovska, Vesna, Budge, Marc, Sim, Edith
Udgivet 2004

Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis

af Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith, Noble, Martin
Udgivet 2005

Activation of nitrofurazone by azoreductases: multiple activities in one enzyme

af Ryan, Ali, Kaplan, Elise, Laurieri, Nicola, Lowe, Edward, Sim, Edith
Udgivet 2011

Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism

af Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Griffiths, William J., Sim, Edith
Udgivet 2007

Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases

af Ryan, Ali, Wang, Chan-Ju, Laurieri, Nicola, Westwood, Isaac, Sim, Edith
Udgivet i Protein Cell (2010)

Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases

af Ballester, Pedro J., Westwood, Isaac, Laurieri, Nicola, Sim, Edith, Richards, W. Graham
Udgivet 2010

Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature

af Hein, David W., Boukouvala, Sotiria, Grant, Denis M., Minchin, Rodney F., Sim, Edith
Udgivet 2008

Purification of human C3b inactivator by monoclonal-antibody affinity chromatography

af Hsiung, Li-min, Barclay, A. Neil, Brandon, Malcolm R., Sim, Edith, Porter, Rodney R.
Udgivet 1982

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

af Sandy, James, Mushtaq, Adeel, Holton, Simon J., Schartau, Pamela, Noble, Martin E. M., Sim, Edith
Udgivet 2005

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system

af Wakefield, Larissa, Cornish, Valerie, Long, Hilary, Kawamura, Akane, Zhang, Xiaoyan, Hein, David W., Sim, Edith
Udgivet 2008

Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

af Wang, Chan-Ju, Laurieri, Nicola, Abuhammad, Areej, Lowe, Edward, Westwood, Isaac, Ryan, Ali, Sim, Edith
Udgivet 2009

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site

af Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Garman, Elspeth F., Sim, Edith
Udgivet i Protein Cell (2010)

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1

af Kawamura, Akane, Westwood, Isaac, Wakefield, Larissa, Long, Hilary, Zhang, Naixia, Walters, Kylie, Redfield, Christina, Sim, Edith
Udgivet 2008

Downregulation of Hepatic Acetylation of Drugs in Chronic Renal Failure

af Simard, Emilie, Naud, Judith, Michaud, Josée, Leblond, Francois A., Bonnardeaux, Alain, Guillemette, Chantal, Sim, Edith, Pichette, Vincent
Udgivet 2008

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues

af Tsirka, Theodora, Konstantopoulou, Maria, Sabbagh, Audrey, Crouau-Roy, Brigitte, Ryan, Ali, Sim, Edith, Boukouvala, Sotiria, Fakis, Giannoulis
Udgivet i Sci Rep (2018)

Exploration of Piperidinols as Potential Antitubercular Agents

af Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela J., Morris, Garrett M., Finn, Paul W., Sim, Edith
Udgivet i Molecules (2014)