Downregulation of Hepatic Acetylation of Drugs in Chronic Renal Failure

Drug metabolism can be affected by chronic renal failure (CRF). Although it is known that several drugs that are known to be acetylated accumulate in CRF, the effect of CRF on N-acetyltransferase (NAT), the enzyme responsible for this acetylation, is unknown. Herein is reported that protein and gene...

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Bibliografiske detaljer
Main Authors: Simard, Emilie, Naud, Judith, Michaud, Josée, Leblond, Francois A., Bonnardeaux, Alain, Guillemette, Chantal, Sim, Edith, Pichette, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2008
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440299/
https://ncbi.nlm.nih.gov/pubmed/18417721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007090974
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