Reduced Hepatic Synthesis of Calcidiol in Uremia

Calcidiol insufficiency is highly prevalent in chronic kidney disease (CKD), but the reasons for this are incompletely understood. CKD associates with a decrease in liver cytochrome P450 (CYP450) enzymes, and specific CYP450 isoforms mediate vitamin D(3) C-25-hydroxylation, which forms calcidiol. Ab...

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Detalhes bibliográficos
Main Authors: Michaud, Josée, Naud, Judith, Ouimet, Denis, Demers, Christian, Petit, Jean-Luc, Leblond, Francois A., Bonnardeaux, Alain, Gascon-Barré, Marielle, Pichette, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013518/
https://ncbi.nlm.nih.gov/pubmed/20595682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009080815
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