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Activation of nitrofurazone by azoreductases: multiple activities in one enzyme
Azoreductases are well known for azo pro-drug activation by gut flora. We show that azoreductases have a wider role in drug metabolism than previously thought as they can also reduce and hence activate nitrofurazone. Nitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3216550/ https://ncbi.nlm.nih.gov/pubmed/22355582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00063 |
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