Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

Azoreductase 1 from Pseudomonas aeruginosa strain PAO1 (paAzoR1) catalyses the activation of the prodrug balsalazide and reduces the azo dye methyl red using reduced nicotinamide adenine dinucleotide cofactor as an electron donor. To investigate the mechanism of the enzyme, a Y131F mutation was intr...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Chan-Ju, Laurieri, Nicola, Abuhammad, Areej, Lowe, Edward, Westwood, Isaac, Ryan, Ali, Sim, Edith
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2009
Konular:
Structural Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805523/
https://ncbi.nlm.nih.gov/pubmed/20057057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109044741
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