Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide

Azoreductase 1 from Pseudomonas aeruginosa strain PAO1 (paAzoR1) catalyses the activation of the prodrug balsalazide and reduces the azo dye methyl red using reduced nicotinamide adenine dinucleotide cofactor as an electron donor. To investigate the mechanism of the enzyme, a Y131F mutation was intr...

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Hlavní autoři: Wang, Chan-Ju, Laurieri, Nicola, Abuhammad, Areej, Lowe, Edward, Westwood, Isaac, Ryan, Ali, Sim, Edith
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2009
Témata:
Structural Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805523/
https://ncbi.nlm.nih.gov/pubmed/20057057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109044741
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