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Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases

The Jumonji C (JmjC) family of 2-oxoglutarate (2OG)-dependent oxygenases have established roles in the regulation of transcription via the catalysis of demethylation of Nε-methylated lysine residues in histone tails, especially the N-terminal tail of histone H3. Most human JmjC N(ɛ)-methyl lysine de...

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Detalhes bibliográficos
Publicado no:Philos Trans R Soc Lond B Biol Sci
Main Authors: Bonnici, Joanna, Tumber, Anthony, Kawamura, Akane, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915715/
https://ncbi.nlm.nih.gov/pubmed/29685975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0071
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