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A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1
The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest family of histone lysine demethylases. There is interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy-8-hydroxyquinoline (IOX1) is the most potent broa...
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| izdano v: | ChemMedChem |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
WILEY-VCH Verlag
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4503230/ https://ncbi.nlm.nih.gov/pubmed/24504543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300428 |
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