A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1

The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest family of histone lysine demethylases. There is interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy-8-hydroxyquinoline (IOX1) is the most potent broa...

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發表在:ChemMedChem
Main Authors: Schiller, Rachel, Scozzafava, Giuseppe, Tumber, Anthony, Wickens, James R, Bush, Jacob T, Rai, Ganesha, Lejeune, Clarisse, Choi, Hwanho, Yeh, Tzu-Lan, Chan, Mun Chiang, Mott, Bryan T, McCullagh, James S O, Maloney, David J, Schofield, Christopher J, Kawamura, Akane
格式: Artigo
語言:Inglês
出版: WILEY-VCH Verlag 2014
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503230/
https://ncbi.nlm.nih.gov/pubmed/24504543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300428
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