Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation

The JmjC histone lysyl demethylases (KDMs) play important roles in modulating histone methylation states and have the potential to be regulated by oxygen availability. Lys241 of the KDM4 subfamily is proposed to be important in oxygen binding by KDM4A. We report evidence that, although Lys241 is unl...

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Udgivet i:Chembiochem
Main Authors: Hancock, Rebecca L., Abboud, Martine I., Smart, Tristan J., Flashman, Emily, Kawamura, Akane, Schofield, Christopher J., Hopkinson, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969224/
https://ncbi.nlm.nih.gov/pubmed/29443450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800002
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