Human histone demethylase KDM6B can catalyse sequential oxidations

Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of N(ε)-methylated lysines on histones and play important roles in gene regulation. We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues. The results unexpectedly reveal...

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Bibliographic Details
Published in:Chem Commun (Camb)
Main Authors: Hopkinson, Richard J., Langley, Gareth W., Belle, Roman, Walport, Louise J., Dunne, Kate, Münzel, Martin, Salah, Eidarus, Kawamura, Akane, Claridge, Timothy D. W., Schofield, Christopher J.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044289/
https://ncbi.nlm.nih.gov/pubmed/29961803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc04057e
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